• Product name

  Human Annexin A1/ANXA1 peptide
  See all Annexin A1/ANXA1 proteins and peptides

• Animal free

  No

• Nature

  Synthetic

• • Species

    Human

• Alternative names

  • Annexin 1
  • Annexin A1
  • Annexin I

  • Annexin I (lipocortin I)
  • Annexin-1
  • AnnexinA1
  • AnnexinI
  • ANX 1
  • ANX A1
  • ANX1
  • ANXA 1
  • ANXA1
  • ANXA1 protein
  • ANXA1_HUMAN
  • Calpactin 2
  • Calpactin II
  • Calpactin-2
  • CalpactinII
  • Chromobindin 9
  • Chromobindin-9
  • Chromobindin9
  • HGNC:533
  • Lipocortin 1
  • Lipocortin I
  • Lipocortin1
  • LipocortinI
  • LPC 1
  • LPC1
  • p35
  • Phospholipase A2 inhibitory protein

  see all

• Function

  Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.

• Sequence similarities

  Belongs to the annexin family.
  Contains 4 annexin repeats.

• Domain

  A pair of annexin repeats may form one binding site for calcium and phospholipid.

• Post-translational
  modifications

  Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity.

• Cellular localization

  Nucleus. Cytoplasm. Cell projection > cilium. Basolateral cell membrane. Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages.

• Target information above from: UniProt accession P04083 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt