HENECA, A2A receptor agonist (ab120458)
Key features and details
- Selective A2A receptor agonist
- CAS Number: 141018-30-6
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 50 mM (with heating)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
HENECA, A2A receptor agonist -
Description
Selective A2A receptor agonist -
Biological description
Selective A2A receptor agonist (Ki = 2.2 nM). Shows good selectivity for A2A over A1 receptors. Displays antiaggregatory activity. Increases cAMP accumulation (EC50 = 43 nM) and inhibits superoxide anion production (EC50 = 3.63 nM) in neutrophils.
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Purity
> 99% -
CAS Number
141018-30-6 -
Chemical structure
Properties
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Chemical name
2-Hexynyladenosine-5'-N-ethylcarboxamide -
Molecular weight
388.42 -
Molecular formula
C18H24N6O4 -
PubChem identifier
4438292 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 50 mM (with heating) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCNC(=O)C3OC(n2cnc1c(N)nc(C#CCCCC)nc12)C(O)C3O -
Source
Synthetic
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Research areas
Images
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Cellular activation - HENECA, A2A receptor agonist (ab120458) Image from Nagpure B V, et al. Plos One, 9(2), e88508. Fig 1a,; doi: 10.1371/journal.pone.0088508
Concentration-dependent effect of HENECA (10-200 nM, 24 hours) on Aβ42 production.
