HC 067047, TRPV4 antagonist (ab145868)
Key features and details
- Potent and selective reversible TRPV4 antagonist
- CAS Number: 883031-03-6
- Purity: > 99%
- Soluble in ethanol to 50 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
HC 067047, TRPV4 antagonist -
Description
Potent and selective reversible TRPV4 antagonist -
Biological description
Potent and selective reversible TRPV4 antagonist (IC50 values are 17, 48 and 133 nM for mouse, human and rat orthologs, respectively.) Potently inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). Shows antivasoconstrictive effects in vivo.
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Purity
> 99% -
CAS Number
883031-03-6 -
Chemical structure
Properties
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Chemical name
2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide -
Molecular weight
471.52 -
Molecular formula
C26H28F3N3O2 -
PubChem identifier
2742550 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 50 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(C=C(N1CCCN2CCOCC2)C3=CC=CC=C3)C(=O)NC4=CC=CC(=C4)C(F)(F)F -
Source
Synthetic
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Research areas
