GW5074, c-Raf1 kinase inhibitor (ab144527)
Key features and details
- Potent, selective and cell-permeable c-Raf1 kinase inhibitor
- CAS Number: 220904-83-6
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GW5074, c-Raf1 kinase inhibitor -
Description
Potent, selective and cell-permeable c-Raf1 kinase inhibitor -
Biological description
Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). Inhibits ATF-3 expression. Shows neuroprotective effects in vivo. Blood-brain barrier permeable. -
Purity
> 98% -
CAS Number
220904-83-6 -
Chemical structure
Properties
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Chemical name
(3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one -
Molecular weight
520.95 -
Molecular formula
C15H8Br2INO2 -
PubChem identifier
5924208 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC2=C(C=C1I)/C(=C/C3=CC(=C(C(=C3)Br)O)Br)/C(=O)N2 -
Source
Synthetic
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Research areas