GSK872, Necroptosis inhibitor (ab254395)
Key features and details
- Highly potent, selective RIP3 inhibitor
- CAS Number: 1346546-69-7
- Purity: > 98%
Soluble in DMSO up to 50mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
GSK872, Necroptosis inhibitor -
Description
Highly potent, selective RIP3 inhibitor -
Alternative names
- GSK'872
- GSK2399872A
-
Biological description
Highly potent, selective receptor interacting protein 3 (RIP3) inhibitor (IC50 = 1.3nM). Selectivty for RIP3 is over 100-fold more compared to other kinases. At high concentrations (3-10μM) can induce Caspase 8-mediated apoptosis. Increases HIF-1a expression after ischaemic injury in vivo. Blocks necroptosis in primary human neutrophils, TNF-induced necroptosis in HT-29 cells and inhibits TLR3- and DAI-induced death in vitro.
-
Purity
> 98% -
General notes
Solutions in DMSO can be stored for up to 1 month.
-
CAS Number
1346546-69-7 -
Chemical structure
Properties
-
Chemical name
N-(6-Propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine
-
Molecular weight
383.48 -
Molecular formula
C19H17N3O2S2 -
PubChem identifier
54674134 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO up to 50mM
-
Handling
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=CC4=C(C=C3)SC=N4 -
Source
Synthetic
