GSK429286A (DMSO solution), Rho kinase 1 and 2 inhibitor (ab146632)
Key features and details
- Potent, selective, cell-permeable Rho kinase 1 and 2 inhibitor
- CAS Number: 864082-47-3
- Purity: > 98%
- Supplied in DMSO (10 mM)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
GSK429286A (DMSO solution), Rho kinase 1 and 2 inhibitor -
Description
Potent, selective, cell-permeable Rho kinase 1 and 2 inhibitor -
Biological description
Potent, selective, cell-permeable Rho kinase 1 and 2 inhibitor (IC50 values are 14 and 63 nM for ROCK1 and ROCK2 respectively). GSK429286A (ab146581) solution. Blocks cell rounding. Shows antihypertensive effect in vivo. Orally active. -
Purity
> 98% -
CAS Number
864082-47-3 -
Chemical structure
Properties
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Chemical name
4-[4-(Trifluoromethyl)phenyl]-N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide -
Molecular weight
432.37 -
Molecular formula
C21H16F4N4O2 -
PubChem identifier
11373846 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Supplied in DMSO (10 mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(C=C4C(=C3)C=NN4)F -
Source
Synthetic
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Research areas
