AY 9944 dihydrochloride, Hedgehog signaling inhibitor (ab145880)
Key features and details
- Hedgehog signaling inhibitor. Potent Δ7-dehydrocholesterol reductase inhibitor.
- CAS Number: 366-93-8
- Purity: > 99%
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AY 9944 dihydrochloride, Hedgehog signaling inhibitor -
Description
Hedgehog signaling inhibitor. Potent Δ7-dehydrocholesterol reductase inhibitor. -
Biological description
Hedgehog signaling inhibitor. Potent Δ7-dehydrocholesterol reductase inhibitor (IC50 = 13 nM). Inhibits cholesterol esterification and biosynthesis, and shows teratogenic effects in vivo. Orally active. -
Purity
> 99% -
CAS Number
366-93-8 -
Chemical structure
Properties
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Chemical name
trans-N,N-Bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride -
Molecular weight
464.30 -
Molecular formula
C22H28Cl2N2.2HCl -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Cl.Clc3ccccc3CNC[C@@H]2CC[C@@H](CNCc1ccccc1Cl)CC2 -
Source
Synthetic
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Research areas
