GSK1904529A (ab273432)
Key features and details
- Selective IGF-1R/IR tyrosine kinase inhibitor
- CAS Number: 1089283-49-7
- Purity: > 98%
Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
GSK1904529A -
Description
Selective IGF-1R/IR tyrosine kinase inhibitor -
Biological description
Selective IGF-1R (IC50 = 27 nM in cell) and Insulin Receptor (IC50 = 25 nM) tyrosine kinase inhibitor in cell-free assays. Reversible, ATP-competitive (Ki = 1.6 nM). Blocks ligand induced autophosphorylation of IGF-1R and IR and activation of downstream Akt, IRS-1 and ERK signaling pathways. Inhibits proliferation of various cell lines. Induces G1 cell cycle arrest.
-
Purity
> 98% -
General notes
For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.
-
CAS Number
1089283-49-7 -
Chemical structure
Properties
-
Chemical name
N-(2,6-Difluorophenyl)-5-[3-[2-[[5-ethyl-2-methoxy-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-pyrimidinyl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamide
-
Molecular weight
851.96 -
Molecular formula
C44H47F2N9O5S -
PubChem identifier
25124816 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 50 mM
-
Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CCC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)S(=O)(=O)C)OC)NC4=NC=CC(=N4)C5=C(N=C6N5C=CC=C6)C7=CC(=C(C=C7)OC)C(=O)NC8=C(C=CC=C8F)F -
Source
Synthetic
Images
-
Chemical Structure - GSK1904529A (ab273432)
Chemical structure of GSK1904529A, 1089283-49-7