GSK-690693 hydrochloride, ATP-competitive pan-Akt kinase inhibitor (ab219869)
Key features and details
- Novel ATP-competitive pan-Akt kinase inhibitor
- CAS Number: 937174-76-0
- Purity: > 99%
- Soluble in DMSO to 20 mM and in ethanol to 60 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GSK-690693 hydrochloride, ATP-competitive pan-Akt kinase inhibitor -
Description
Novel ATP-competitive pan-Akt kinase inhibitor -
Alternative names
- GSK 690693 Hydrochloride
- GSK-690693 HCl
- GSK690693 hydrochloride
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Biological description
Novel ATP-competitive pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM for Akt1, 2 and 3 respectively). Also exhibits some inhibition of AMPK, PKA and PAK and PKC isoforms (IC50
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Purity
> 99% -
CAS Number
937174-76-0 -
Chemical structure
Properties
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Chemical name
(S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridine-4-yl)-2-methylbut-3-yn-2-ol hydrochloride -
Molecular weight
461.96 -
Molecular formula
C21H27N7O3.HCl -
PubChem identifier
16725726 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 20 mM and in ethanol to 60 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCN1C2=C(C(=NC=C2OC[C@H]3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N -
Source
Synthetic
