Go 6976, PKC inhibitor (ab141413)
Key features and details
- Potent PKC inhibitor. Selective for PKCα and PKCβ
- CAS Number: 136194-77-9
- Purity: > 99%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Go 6976, PKC inhibitor -
Description
Potent PKC inhibitor. Selective for PKCα and PKCβ -
Biological description
Potent, selective PKC inhibitor (IC50 values are 2.3 and 6.2 nM at PKCα and β1, respectively). Selectively inhibits Ca2+-dependent PKC isoforms over Ca2+-independent. No inhibitory activity at PKCδ, ε or ζ. Antitumor agent. Active in vitro and in vivo.
-
Purity
> 99% -
CAS Number
136194-77-9 -
Chemical structure
Properties
-
Chemical name
5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile -
Molecular weight
378.43 -
Molecular formula
C24H18N4O -
PubChem identifier
3501 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O -
Source
Synthetic
-
Research areas
