GMQ hydrochloride, ASIC3 channel activator (ab146005)
Key features and details
- Selective ASIC3 channel activator. Competitive GABAA receptor antagonist.
- CAS Number: 5361-15-9
- Purity: > 98%
- Soluble in DMSO to 50 mM and in water to 5 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
GMQ hydrochloride, ASIC3 channel activator -
Description
Selective ASIC3 channel activator. Competitive GABAA receptor antagonist. -
Biological description
Selective ASIC3 channel activator at pH 7.4. Alters the pH dependence of ASIC1a and ASIC1b; does not affect the activation curve of ASIC2a. Competitive GABAA receptor antagonist (IC50 = 390 nM). Shows nociceptive effects in vivo. -
Purity
> 98% -
CAS Number
5361-15-9 -
Chemical structure
Properties
-
Chemical name
N-(4-Methyl-2-quinazolinyl)guanidine hydrochloride -
Molecular weight
237.69 -
Molecular formula
C10H11N5.HCl -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM and in water to 5 mM (with warming) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
Source
Synthetic
