gamma-Rubromycin, HIV-1 reverse transcriptase inhibitor (ab144350)
Key features and details
- Selective, reversible HIV-1 reverse transcriptase inhibitor. Telomerase inhibitor.
- CAS Number: 27267-71-6
- Purity: > 98%
- Soluble in DMSO
- Form / State: Solid
- Source: Streptomyces sp.
Overview
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Product name
gamma-Rubromycin, HIV-1 reverse transcriptase inhibitor -
Description
Selective, reversible HIV-1 reverse transcriptase inhibitor. Telomerase inhibitor. -
Biological description
Selective, reversible HIV-1 reverse transcriptase inhibitor. Shows equipotent template:primer competitive, TTP non-competitive RT inhibition as β-Rubromycin (ab144349). Telomerase inhibitor (IC50 = 3 μM, human telomerase). Shows antibacterial and cytostatic effects. -
Purity
> 98% -
CAS Number
27267-71-6 -
Chemical structure
Properties
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Chemical name
Methyl (2S)-4',9',10-trihydroxy-7'-methoxy-5',8',9-trioxospiro[3,4-dihydropyrano[4,3-g]chromene-2,2'-3H-benzo[f][1]benzofuran]-7-carboxylate -
Molecular weight
522.41 -
Molecular formula
C26H18O12 -
PubChem identifier
5464075 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=CC(=O)C2=C(C1=O)C(=C3C(=C2O)C[C@@]4(O3)CCC5=C(O4)C(=C6C(=C5)C=C(OC6=O)C(=O)OC)O)O -
Source
Streptomyces sp.
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Research areas
