Gambogic acid, Apoptotic agent (ab145183)
Key features and details
- Apoptotic agent
- CAS Number: 2752-65-0
- Purity: > 98%
- Soluble in ethanol to 25 mM and in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Gambogic acid, Apoptotic agent -
Description
Apoptotic agent -
Biological description
Cell-permeable caspase activator (EC50 = 0.78 - 1.64 µM). Apoptotic agent. Decreases Bcl-2 and increases Bax expression. Potentiates cisplatin (ab141398)-induced apoptosis. Inhibits angiogenesis. Shows antitumor effects in vivo. Orally active. -
Purity
> 98% -
CAS Number
2752-65-0 -
Chemical structure
Properties
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Chemical name
(2Z)-4-[(2R,8R,17R,19R)-12-Hydroxy-8,21,21-trimethyl-5-(3-methyl-2-buten-1-yl)-8-(4-methyl-3-penten-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.0[2,15].0[2,19].0[4,13].0[6,11]]docosa-4(13),5,9, 11,15-pentaen-19-yl]-2-methyl-2-butenoic acid -
Molecular weight
628.75 -
Molecular formula
C38H44O8 -
PubChem identifier
5281632 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 25 mM and in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(O)C(/C)=C\C[C@]63OC(C)(C)[C@H]2C[C@H](C=C1C(=O)c5c(OC123)c(C\C=C(/C)C)c4O[C@](C)(CC\C=C(/C)C)C=Cc4c5O)C6=O -
Source
Synthetic
