Galiellalactone, STAT3 signaling inhibitor (ab145647)
Key features and details
- Selective STAT3 signaling inhibitor
- CAS Number: 133613-71-5
- Purity: > 95%
- Soluble in ethanol and in DMSO
- Form / State: Solid
- Source: Galiella rufa
Overview
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Product name
Galiellalactone, STAT3 signaling inhibitor -
Description
Selective STAT3 signaling inhibitor -
Biological description
Selective STAT3 signaling inhibitor (IC50 = 0.25-0.5 μM, IL-6-mediated JAK/STAT signaling). Selectively blocks binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor. Induces apoptosis. Shows antitumor and anti-inflammatory effects in vivo. -
Purity
> 95% -
CAS Number
133613-71-5 -
Chemical structure
Properties
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Chemical name
(4S,5aR,7aR,7bS)-7b-Hydroxy-4-methyl-5,5a,6,7,7a,7b-hexahydroindeno[1,7-bc]furan-2(4H)-one -
Molecular weight
194.23 -
Molecular formula
C11H14O3 -
PubChem identifier
6711856 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol and in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@H]1C[C@@H]2CC[C@H]3[C@@]2(C(=C1)C(=O)O3)O -
Source
Galiella rufa
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Research areas
