BIX 02188, MEK5 inhibitor (ab144572)
Key features and details
- Potent, selective MEK5 inhibitor
- CAS Number: 334949-59-6
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BIX 02188, MEK5 inhibitor -
Description
Potent, selective MEK5 inhibitor -
Biological description
Potent, selective MEK5 inhibitor (IC50 = 4.3 nM). Blocks phosphorlyation of ERK5, without affecting phosphorylation of ERK1/2. Induces apoptosis in FLT3-ITD cells. Centrally active in vivo.
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Purity
> 98% -
CAS Number
334949-59-6 -
Chemical structure
Properties
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Chemical name
(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide -
Molecular weight
412.49 -
Molecular formula
C25H24N4O2 -
PubChem identifier
66524294 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)Cc1cc(ccc1)N/C(=C2/c3ccc(cc3NC2=O)C(N)=O)c4ccccc4 -
Source
Synthetic
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Research areas
