G10, STING signaling activator (ab230375)
Key features and details
- Indirect activator of stimulator of interferon genes (STING) signaling
- CAS Number: 702662-50-8
- Purity: > 98%
Soluble in DMSO to 100mM and in ethanol to 50 mM.
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
G10, STING signaling activator -
Description
Indirect activator of stimulator of interferon genes (STING) signaling -
Alternative names
- STING Agonist-1
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Biological description
G10 is an indirect activator or stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC90s = 8.01 and 24.57 µM, respectively). G10 (100 µM) increases phosphorylation of IRF3, which is lost in cells lacking STING.
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Purity
> 98% -
CAS Number
702662-50-8 -
Chemical structure
Properties
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Excitation
253nm -
Emission
292nm -
Chemical name
4-[(2-Chloro-6-fluorophenyl)methyl]-N-(furan-2-ylmethyl)-3-oxo-1,4-benzothiazine-6-carboxamide
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Molecular weight
430.88 -
Molecular formula
C21H16ClFN2O3S -
PubChem identifier
5077622 -
Storage instructions
Shipped at 4°C. Store at -20°C long term. -
Solubility overview
Soluble in DMSO to 100mM and in ethanol to 50 mM.
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SMILES
C1C(=O)N(C2=C(S1)C=CC(=C2)C(=O)NCC3=CC=CO3)CC4=C(C=CC=C4Cl)F -
Source
Synthetic
