Entinostat (MS-275) (ab142053)
Key features and details
- HDAC1 and HDAC3 inhibitor
- CAS Number: 209783-80-2
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Entinostat (MS-275) -
Description
HDAC1 and HDAC3 inhibitor -
Alternative names
- Entinosta (MS-275)
- Entinostat
- MS-275
- SNDX-275
-
Biological description
Benzamide derivative that inhibits histone deacetylase 1 (HDAC1) and HDAC2. Not active against HDAC4, 6, 8 and 10 (IC50 >100μM). Exhibits anticancer chemotherapeutic, anti-metastatic, and neuroprotective properties. In vitro, it increases transcription of E-cadherin and decreases transcription of N-cadherin, decreasing tubulin-based microtentacles, reversing epithelial-to-mesenchymal transition (EMT) and inhibiting cell migration. Upregulates natural killer cell activating receptor NKG2D. Increases ability of natural killer cells to destroy cancer cells. Down regulates cellular FLICE-inhibiting protein (c-FLIP), increasing caspase activation and inducing apoptosis in animal models. Inhibition of HDAC1 in the nucleus accumbens (NAcc) inhibits cocaine-induced plasticity and behavioral changes in rodent models. Decreases amyloid-beta (Abeta) deposition in the hippocampus and cortex of animal models.
-
Purity
> 99% -
CAS Number
209783-80-2 -
Chemical structure
Properties
-
Chemical name
Pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate -
Molecular weight
376.41 -
Molecular formula
C21H20N4O3 -
PubChem identifier
4261 -
Storage instructions
Shipped at Room Temperature. Store at Room Temperature. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3 -
Source
Synthetic
-
Research areas
- Epigenetics and Nuclear Signaling
- Chromatin Modifying Enzymes
- Acetylation
- HDACs
- Class II / Hda1 Class
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
