Emtricitabine, reverse transcriptase inhibitor (ab145045)
Key features and details
- Competitive reverse transcriptase inhibitor. Nucleoside analog.
- CAS Number: 143491-57-0
- Soluble in water to 100 mM, in ethanol to 50 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Emtricitabine, reverse transcriptase inhibitor -
Description
Competitive reverse transcriptase inhibitor. Nucleoside analog. -
Biological description
Competitive reverse transcriptase inhibitor. Nucleoside analog. Shows antiviral effects against HIV and HBV in vivo (IC50 values are 7 - 75 nM for HIV-1). Structurally related to Lamivudine (ab143062). Orally active. Blood-brain barrier permeable. -
CAS Number
143491-57-0 -
Chemical structure
Properties
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Chemical name
4-Amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one -
Molecular weight
247.25 -
Molecular formula
C8H10FN3O3S -
PubChem identifier
60877 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM, in ethanol to 50 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1[C@H](O[C@H](S1)CO)N2C=C(C(=NC2=O)N)F -
Source
Synthetic
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Research areas
