EI1, EZH2 inhibitor (ab269817)
Key features and details
- Potent and selective EZH2 inhibitor
- CAS Number: 1418308-27-6
Soluble in DMSO to 50 mM
- Form / State: Solid
Overview
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Product name
EI1, EZH2 inhibitor -
Description
Potent and selective EZH2 inhibitor -
Biological description
Potent (IC50 = 15 nM for wild-type enzyme; 13 nM for Y641F mutant enzyme) EZH2 inhibitor. Selective versus EZH1 (142-fold). Highly selective (>10,000-fold) against a panel of 10 other human methyltransferases. Inhibits cellular H3K27 methylation and activates Ezh2 target gene p16 expression in diffuse large B-cell lymphoma cells (DLBLC). Selectively inhibits growth and promotes cell cycle arrest and apoptosis of DLBLC cells with Y641 EZH2 mutations.
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CAS Number
1418308-27-6 -
Chemical structure
Properties
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Chemical name
6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1- ethylpropyl)-1H-indole-4-carboxamide -
Molecular weight
390.48 -
Molecular formula
C23H26N4O2 -
PubChem identifier
72199293 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 50 mM
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Handling
Toxic, refer to SDS for further information.
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SMILES
CCC(CC)N1C=CC2=C(C=C(C=C21)C#N)C(=O)NCC3=C(C=C(NC3=O)C)C
Images
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Chemical Structure - EI1, EZH2 inhibitor (ab269817)
Chemical structure of EI1, EZH2 inhibitor, 1418308-27-6