E6 Berbamine, calmodulin (CaM) antagonist (ab141519)
Key features and details
- Selective, cell-permeable calmodulin (CaM) antagonist
- CAS Number: 114784-59-7
- Purity: > 98%
- Soluble in DMSO to 25 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
E6 Berbamine, calmodulin (CaM) antagonist -
Description
Selective, cell-permeable calmodulin (CaM) antagonist -
Biological description
Selective, cell-permeable CaM antagonist. Berbamine derivative. Inhibits calmodulin-dependent MYLK and PDE I (IC50 values are 8 and 0.53 μM for MYLK and PDE1 respectively). -
Purity
> 98% -
CAS Number
114784-59-7 -
Chemical structure
Properties
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Chemical name
6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-yl acetate -
Molecular weight
757.80 -
Molecular formula
C44H43N3O9 -
PubChem identifier
6610268 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM and in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC(=O)C8=CC=C(C=C8)[N+](=O)[O-])OC -
Source
Synthetic
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Research areas
