E-64d (Aloxistatin), cathepsin B and L inhibitor (ab144048)
Key features and details
- Irreversible cell-permeable cathepsin B and L inhibitor
- CAS Number: 88321-09-9
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
E-64d (Aloxistatin), cathepsin B and L inhibitor -
Description
Irreversible cell-permeable cathepsin B and L inhibitor -
Alternative names
- Aloxistatin
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Biological description
Irreversible cell-permeable cathepsin B and L inhibitor. Inhibits calpain. Inhibits autophagy. Inhibits platelet proteolysis. Reduces brain amyloid-β levels. Shows neuroprotective effects in vivo. -
Purity
> 98% -
CAS Number
88321-09-9 -
Chemical structure
Properties
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Chemical name
Ethyl (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate -
Molecular weight
342.43 -
Molecular formula
C17H30N2O5 -
PubChem identifier
65663 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCOC(=O)C1C(O1)C(=O)NC(CC(C)C)C(=O)NCCC(C)C -
Source
Synthetic
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Research areas
