E-4031 dihydrochloride, HERG K+ channel blocker (ab120158)
Key features and details
- HERG K+ channel blocker
- CAS Number: 113559-13-0
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
E-4031 dihydrochloride, HERG K+ channel blocker -
Description
HERG K+ channel blocker -
Alternative names
- E4031
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Biological description
Type III antiarrhythmic drug that blocks ion channels encoded by the ether-a-go-go related gene (ERG1 or KCNH1). Blocks channels in the open configuration with little effect on the channels in the closed configuration. The IC50 for block of human ERG channels in expression systems is approx. 350 nM.
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Purity
> 99% -
CAS Number
113559-13-0 -
Chemical structure
Properties
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Chemical name
N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride -
Molecular weight
474.44 -
Molecular formula
C21H27N3O3S.2HCl -
PubChem identifier
3087190 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Cl.CS(=O)(=O)Nc1ccc(cc1)C(=O)C3CCN(CCc2cccc(C)n2)CC3 -
Source
Synthetic
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Research areas
