DR2313 (PARP Inhibitor XI), brain-penetrant PARP inhibitor (ab120368)
Key features and details
- Potent, brain-penetrant and water-soluble PARP inhibitor
- CAS Number: 284028-90-6
- Purity: > 99%
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
DR2313 (PARP Inhibitor XI), brain-penetrant PARP inhibitor -
Description
Potent, brain-penetrant and water-soluble PARP inhibitor -
Alternative names
- PARP Inhibitor XI
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Biological description
Potent, brain-penetrant, and water-soluble poly(ADP-ribose) polymerase (PARP) inhibitor. IC50 values are 0.20 and 0.24 µM for PARP-1 and PARP-2, respectively. Neuroprotective in vitro and in vivo.
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Purity
> 99% -
CAS Number
284028-90-6 -
Chemical structure
Properties
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Chemical name
1,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one -
Molecular weight
182.24 -
Molecular formula
C8H10N2OS -
PubChem identifier
10219702 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C1N=C(C)NC=2CCSCC1=2 -
Source
Synthetic
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Research areas