DIDS, chloride channel blocker (ab120277)
Key features and details
- Generic chloride channel blocker.
- CAS Number: 67483-13-0
- Soluble in DMSO and in water
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
DIDS, chloride channel blocker -
Description
Generic chloride channel blocker. -
Alternative names
- 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic Acid, Disodium Salt
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Biological description
Stilbene disulfonate that inhibits anionic transport. Used to inhibit Cl- uptake through plasma membrane-localized Cl- channels in order to study chloride transport. Also effectively inhibits various sodium-coupled bicarbonate transporters. Reacts with CD4 glycoprotein on T helper lymphocytes and macrophages, blocking HIV type-1 growth at multiple stages of the viral life cycle.
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General notes
Fluorescence: max. Abs. l = 341, max. Em. l = 415 (in water).
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CAS Number
67483-13-0 -
Chemical structure
Properties
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Excitation
341nm -
Emission
415nm -
Chemical name
4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid disodium salt -
Molecular weight
498.50 -
Molecular formula
C16H8N2Na2O6S4 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO and in water -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
