Dexrazoxane hydrochloride, Topoisomerase II inhibitor (ab141109)
Key features and details
- Topoisomerase II inhibitor. Intracellular ion chelator.
- CAS Number: 149003-01-0
- Purity: > 98%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Dexrazoxane hydrochloride, Topoisomerase II inhibitor -
Description
Topoisomerase II inhibitor. Intracellular ion chelator. -
Biological description
Topoisomerase II inhibitor. Intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters. Reduces ROS° production and activates the PI3K/Akt survival pathway. Cardioprotective effects when co-administered with doxorubicin (ab142006) in vivo.
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Purity
> 98% -
CAS Number
149003-01-0 -
Chemical structure
Properties
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Chemical name
4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis-2,6-piperazinedione hydrochloride -
Molecular weight
304.73 -
Molecular formula
C11H16N4O4.HCl -
PubChem identifier
71384 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.O=C2CN(C[C@H](C)N1CC(=O)NC(=O)C1)CC(=O)N2 -
Source
Synthetic
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Research areas
