Desloratadine, H1 receptor antagonist (ab142280)
Key features and details
- Highly potent, selective H1 receptor antagonist
- CAS Number: 100643-71-8
- Purity: > 97%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Desloratadine, H1 receptor antagonist -
Description
Highly potent, selective H1 receptor antagonist -
Biological description
Highly potent, selective H1 receptor antagonist (Ki = 0.97 pM). Inhibits release of inflammatory mediators, including IL-4, IL-6, IL-8, IL-13, PGD(2), leukotriene C4 and tryptase. Anti-inflammatory and antihistaminergic. Orally active. Active in vivo and in vitro. -
Purity
> 97% -
CAS Number
100643-71-8 -
Chemical structure
Properties
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Chemical name
8-Chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine -
Molecular weight
310.82 -
Molecular formula
C19H19ClN2 -
PubChem identifier
124087 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4 -
Source
Synthetic
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Research areas
