Deltamethrin, protein phosphatase 2B inhibitor (ab141019)
Key features and details
- Potent protein phosphatase 2B inhibitor
- CAS Number: 52918-63-5
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Deltamethrin, protein phosphatase 2B inhibitor -
Description
Potent protein phosphatase 2B inhibitor -
Biological description
Potent protein phosphatase 2B inhibitor (IC50 = 0.03 nM). Induces neurotoxicity by slowing the opening and closing of Na+ channels. Active in vivo.
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Purity
> 98% -
CAS Number
52918-63-5 -
Chemical structure
Properties
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Chemical name
(S)-Cyano-(3-phenoxyphenyl)methyl (1R,3R)-3-(2,2-dibromoethenyl)-2,2-
dimethylcyclopropanecarboxylate -
Molecular weight
505.21 -
Molecular formula
C22H19Br2NO3 -
PubChem identifier
40585 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Br/C(Br)=C/[C@H]3[C@@H](C(=O)O[C@H](C#N)c2cccc(Oc1ccccc1)c2)C3(C)C -
Source
Synthetic
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Research areas
Images
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Functional Studies - Deltamethrin, protein phosphatase 2B inhibitor (ab141019)ab11419 staining DDIT3 in SKNSH cells treated with deltamethrin (ab141019), by ICC/IF. Increase of DDIT3 expression correlates with increased concentration of deltamethrin, as described in literature.
The cells were incubated at 37°C for 48 hours in media containing different concentrations of ab141019 (deltamethrin) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab11419 (10 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
