CyPPA, SK channel activator (ab120829)
Key features and details
- First selective SK channel activator
- CAS Number: 73029-73-9
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
CyPPA, SK channel activator -
Description
First selective SK channel activator -
Biological description
First selective small conductance Ca2+-activated K+ channel (SK) activator. Selectively opens SK2 and SK3 channels (EC50 values are 5.6 and 14 μM, respectively). Shows no activity at SK1 and IK. Additionally reduces activity and excitability of dopamine neurons. Active in vivo.
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Purity
> 98% -
CAS Number
73029-73-9 -
Chemical structure
Properties
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Chemical name
N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-4-pyrimidinamine -
Molecular weight
285.39 -
Molecular formula
C16H23N5 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
