Cyclopamine-KAAD, Smo/Hh/GLI1 signaling inhibitor (ab142146)
Key features and details
- Cell-permeable Smo/Hh/GLI1 signaling inhibitor
- CAS Number: 306387-90-6
- Purity: > 80%
- Soluble in DMSO and in ethanol
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Cyclopamine-KAAD, Smo/Hh/GLI1 signaling inhibitor -
Description
Cell-permeable Smo/Hh/GLI1 signaling inhibitor -
Biological description
Cell-permeable Smoothened, Sonic hedgehog and GLI1 signaling inhibitor. Cyclopamine derivative (ab120392). Suppresses the constitutive pathway activation resulting from loss of Ptch1 function (IC50 = 20 nM). -
Purity
> 80% -
CAS Number
306387-90-6 -
Chemical structure
Properties
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Chemical name
N-[2-[(3'R,7'aR)-3',6',10,11b-tetramethyl-3-oxospiro[1,2,4,6,6a,6b,7,8, 11,11a-decahydrobenzo[a]fluorene-9,2'-3,3a,5,6,7,7a-hexahydrofuro[3,2-b]pyridine]-4'-yl]ethyl]-6-(3-phenylpropanoylamino)hexanamide -
Molecular weight
697.99 -
Molecular formula
C44H63N3O4 -
PubChem identifier
16760383 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO and in ethanol -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(=O)CCC6(C5CC4=C3C)C)C)N(C1)CCNC(=O)CCCCCNC(=O)CCC7=CC=CC=C7 -
Source
Synthetic
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Research areas
