Cryptotanshinone, STAT3 inhibitor (ab120666)
Key features and details
- STAT3 inhibitor with diverse biological activities
- CAS Number: 35825-57-1
- Purity: > 97%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Salvia miltiorrhiza
Overview
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Product name
Cryptotanshinone, STAT3 inhibitor -
Description
STAT3 inhibitor with diverse biological activities -
Biological description
STAT3 inhibitor (IC50 = 4.6 μM). Cell-permeable, naturally occuring constitutent of Salvia miltiorrhiza with diverse biological activities. Shows anticancer, antibacterial, anti-inflammatory, antidiabetes and antiobesity activity. Attenuates amyloid plaque deposition in the brain.
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Purity
> 97% -
CAS Number
35825-57-1 -
Chemical structure
Properties
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Chemical name
(R)-(-)-1,6,6-Trimethyl-1,2,6,7,8,9-hexahydrophenanthro[1,2-b]furan-10,11-dione -
Molecular weight
296.37 -
Molecular formula
C19H20O3 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Salvia miltiorrhiza
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Research areas
- Biochemicals
- Research Area
- Pain & inflammation
- Signaling
- Cytokine and NF-κB signaling
- STAT
- Inhibitors
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- JAK/STAT signaling
- STAT
- Inhibitors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- JAK/STAT signaling
- STAT
- Inhibitors
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- JAK/STAT signaling
- STAT
- Inhibitors
Images
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Functional Studies - Cryptotanshinone, STAT3 inhibitor (ab120666)
MCF7 cells were incubated at 37°C for 4h with vehicle control (0 µM) and different concentrations of cryptotanshinone (ab120666). Increased expression of JNK1+JNK2 (phospho T183 + Y185) in MCF7cells correlates with an increase in cryptotanshinone concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 10 µg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with ab4821 at at 1/1000 dilution and ab8227 at 1 µg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (ab97051) at 1/10000 dilution and visualised using ECL development solution.