Crizotinib, c-MET and ALK receptor tyrosine kinase inhibitor (ab218605)
Key features and details
- Potent, selective c-MET and ALK receptor tyrosine kinase inhibitor
- CAS Number: 877399-52-5
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Crizotinib, c-MET and ALK receptor tyrosine kinase inhibitor -
Description
Potent, selective c-MET and ALK receptor tyrosine kinase inhibitor -
Alternative names
- PF 02341066
- PF 2341066
- PF02341066
- Xalkori
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Biological description
Potent, ATP-competitive inhibitor of c-MET and anaplastic lymphoma kinase (ALK) receptor tyrosine kinases (cell IC50 values are 8.0 and 20 nM respectively). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple tumor models; inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro. Orally bioavailable.
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Purity
> 98% -
CAS Number
877399-52-5 -
Chemical structure
Properties
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Chemical name
3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine -
Molecular weight
450.34 -
Molecular formula
C21H22Cl2FN5O -
PubChem identifier
11626560 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N -
Source
Synthetic