Cinacalcet hydrochloride (ab254224)
Key features and details
- Calcium sensing receptor agonist
- CAS Number: 364782-34-3
- Purity: > 99%
Soluble in DMSO to 100mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Cinacalcet hydrochloride -
Description
Calcium sensing receptor agonist -
Alternative names
- AMG-073 HCl
- KRN 1493
- Mimpara
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Biological description
Ca2+-sensing receptor agonist that is clinically used to treat secondary hyperparathyroidism with chronic kidney disease. Cinacalcet also displays anti-fibrotic activity. Decreases levels of parathyroid hormone (PTH), increases adiponectin secretion, lowers oxidative stress and displays anti fibrotic activity. Increases sensitivity of Ca2+-sensing receptors to serum Ca2+ levels. In vivo. Decreases renal epithelial-to-mesenchymal transition (EMT) and prevents the development of renal fibrosis.
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Purity
> 99% -
CAS Number
364782-34-3 -
Chemical structure
Properties
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Chemical name
N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propanamine hydrochloride
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Molecular weight
393.88 -
Molecular formula
C22H22F3N.HCl -
PubChem identifier
156418 -
Storage instructions
Shipped at Room Temperature. Store at Room Temperature. -
Solubility overview
Soluble in DMSO to 100mM
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Handling
Toxic, refer to SDS for further information.
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SMILES
CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl -
Source
Synthetic
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Research areas
