Ciglitazone, PPARgamma agonist (ab141139)
Key features and details
- Selective PPARγ agonist
- CAS Number: 74772-77-3
- Purity: > 98%
- Soluble in DMSO to 100 mM and 1eq. NaOH to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ciglitazone, PPARgamma agonist -
Description
Selective PPARγ agonist -
Biological description
Selective PPARγ agonist (EC50 = 3 µM). Shows antidiabetic and antineoplastic activity. Induces cell cycle arrest and apoptosis. Active in vivo.
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Purity
> 98% -
CAS Number
74772-77-3 -
Chemical structure
Images
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Functional Studies - Ciglitazone, PPARgamma agonist (ab141139)ab19481 staining PPARγ in U-87 MG cells treated with ciglitazone (ab141139), by ICC/IF. Increase of PPARγ cytoplasmic expression correlates with increased concentration of ciglitazone, as described in literature.
The cells were incubated at 37°C for 24 hours in media containing different concentrations of ab141139 (ciglitazone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab19481 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.