Chaetocin, histone lysine methyltransferase inhibitor (ab144534)
Key features and details
- Non-selective histone lysine methyltransferase inhibitor
- CAS Number: 28097-03-2
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Chaetocin, histone lysine methyltransferase inhibitor -
Description
Non-selective histone lysine methyltransferase inhibitor -
Biological description
Non-selective histone lysine methyltransferase inhibitor (IC50 values are0.8, 2.5 and 3 μM for Suv39H1, G9a and DIM5 respectively). Competitive, selective thioredoxin substrate. Induces ROS generation and oxidative stress. Selectively induces apoptosis in cancer cell lines. Shows antiproliferative effects in vivo. -
Purity
> 98% -
CAS Number
28097-03-2 -
Chemical structure
Properties
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Chemical name
(3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)-2,2',3,3',5a,5'a,6,6'-Octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone -
Molecular weight
696.83 -
Molecular formula
C30H28N6O6S4 -
PubChem identifier
161591 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C -
Source
Synthetic
