CGRP (hu, Mod Asp3 to Pra) (ab146956)
Key features and details
- Endogenous vasodilatory neuropeptide.
- Purity: > 95%
Soluble in water to 1mg/ml
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
CGRP (hu, Mod Asp3 to Pra) -
Description
Endogenous vasodilatory neuropeptide. -
Alternative names
- Calcitonin Gene Related Peptide
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Purity
> 95% -
General notes
CGRP (hu, Mod Asp3 to Pra) ab146956 is a 37 amino acid neuroendocrine hormone that belongs to the calcitonin (CT) family. It is a vasodilator and plays an important role in neurogenic inflammation, and therefore has gained significant interest for the treatment of migraine. CGRP exerts effects through the CGRP receptor. To probe receptor binding, labelling with TAMRA azide, 5- isomer, Orange emitting fluorescent dye (ab146486), using Cu(I)-catalysed azide-alkyne cycloaddition (CuAAC) to position 3 of human αCGRP, generates a potent fluorescent CGRP.
Properties
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Chemical name
ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF (Modifications: Asp-3 = Pra; C-terminal amide; Disulfide bonds: 2-7)
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Molecular weight
3770.33 -
Molecular formula
C164H266N50O48S2 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in water to 1mg/ml
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
