CAY10598, EP4 agonist (ab144407)
Key features and details
- Potent, selective EP4 agonist
- CAS Number: 346673-06-1
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
CAY10598, EP4 agonist -
Description
Potent, selective EP4 agonist -
Biological description
Potent, selective EP4 agonist (Ki = 1.2 nM). Demonstrates p53 and Bax induction, cytochrome c release and caspase-9, -7, and -3 and PARP cleavage. Inhibits Bcl-2, Bcl-xL and survivin expression. Induces apoptosis. Inhibits JAK2/STAT3 signaling. Generates ROS. Shows inflammatory effects in vivo. -
Purity
> 98% -
CAS Number
346673-06-1 -
Chemical structure
Properties
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Chemical name
(5R)-5-[(E,3S)-3-Hydroxy-4-phenylbut-1-enyl]-1-[6-(2H-tetrazol-5-yl)hexyl]pyrrolidin-2-one -
Molecular weight
383.49 -
Molecular formula
C21H29N5O2 -
PubChem identifier
9864831 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CC(=O)N([C@H]1/C=C/[C@H](CC2=CC=CC=C2)O)CCCCCCC3=NNN=N3 -
Source
Synthetic
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Research areas
