Captopril, ACE inhibitor (ab141333)
Key features and details
- Potent ACE inhibitor
- CAS Number: 62571-86-2
- Purity: > 98%
- Soluble in water to 100 mM, in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Captopril, ACE inhibitor -
Description
Potent ACE inhibitor -
Biological description
Potent ACE inhibitor (IC50 = 21 nM). Reversible and competitive leukotriene A4 hydrolase inhibitor (Ki = 6 μM, leukotriene B4 formation). Vasodilatory and antihypertensive effects in vivo. Orally active.
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Purity
> 98% -
General notes
In aqueous solution, this product undergoes a free radical dimerisation to form captopril disulfide. This dimerisation is oxygen-facilitated and has been found to be pH dependent and catalysed by metal ions. To delay oxidation use a lower pH (maximum stability at pH
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CAS Number
62571-86-2 -
Chemical structure
Properties
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Chemical name
1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-L-proline -
Molecular weight
217.28 -
Molecular formula
C9H15NO3S -
PubChem identifier
44093 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM, in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Unstable; make up solutions fresh and use immediately.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
OC(=O)[C@@H]1CCCN1C(=O)[C@H](C)CS -
Source
Synthetic
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Research areas
