Cancer cell stemness inhibitor (Napabucasin), high-cancer cell inhibitor (ab145630)
Key features and details
- Potent, broad spectrum stemness high-cancer cell inhibitor
- CAS Number: 83280-65-3
- Purity: > 98%
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Cancer cell stemness inhibitor (Napabucasin), high-cancer cell inhibitor -
Description
Potent, broad spectrum stemness high-cancer cell inhibitor -
Alternative names
- Napabucasin
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Biological description
Potent, broad spectrum stemness high-cancer cell inhibitor (IC50 values are 500 - 1200 nM). Inhibits STAT3-driven gene transcription. Potently prevents self-renewal in cancer stem cells. Shows antineoplastic and antimetastatic effects in vivo. Orally active. -
Purity
> 98% -
CAS Number
83280-65-3 -
Chemical structure
Properties
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Chemical name
2-Acetylbenzo[f][1]benzofuran-4,9-dione -
Molecular weight
240.21 -
Molecular formula
C14H8O4 -
PubChem identifier
10331844 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=O)C1=CC2=C(O1)C(=O)C3=CC=CC=C3C2=O -
Source
Synthetic
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Research areas