Cyclic Pifithrin-alpha hydrobromide, pifithrin-alpha analog (ab144327)
Key features and details
- Stable, cell-permeable analog of pifithrin-α. p53 inhibitor
- CAS Number: 511296-88-1
- Purity: > 98%
- Soluble in ethanol to 25 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Cyclic Pifithrin-alpha hydrobromide, pifithrin-alpha analog -
Description
Stable, cell-permeable analog of pifithrin-α. p53 inhibitor -
Biological description
Stable, cell-permeable analog of pifithrin-α (ab120478). Inhibits p53-mediated apoptosis and p53-dependent gene transcription. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01 μM). Potent STAT6 transcriptional inhibitor. Active in vivo and in vitro.
See similar compound -
Purity
> 98% -
CAS Number
511296-88-1 -
Chemical structure
Properties
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Chemical name
2-(4-Methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole hydrobromide -
Molecular weight
348.28 -
Molecular formula
C16H16N2S.HBr -
PubChem identifier
11515812 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Soluble in ethanol to 25 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2.Br -
Source
Synthetic
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Research areas