BX-795, PDK1 inhibitor (ab142016)
Key features and details
- PDK1 inhibitor. Potent TBK1 and IKKε inhibitor
- CAS Number: 702675-74-9
- Purity: > 97%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BX-795, PDK1 inhibitor -
Description
PDK1 inhibitor. Potent TBK1 and IKKε inhibitor -
Biological description
PDK1 inhibitor. Potent TBK1 and IKKε inhibitor. Blocks PDK1/Akt signaling. Inhibits anchorage-dependent growth of tumor cells. Blocks phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3. Induces G2/M cell cycle arrest. -
Purity
> 97% -
CAS Number
702675-74-9 -
Chemical structure
Properties
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Chemical name
N-(3-(5-Iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide -
Molecular weight
591.47 -
Molecular formula
C23H26IN7O2S -
PubChem identifier
10077147 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I -
Source
Synthetic
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Research areas
