BX 513 hydrochloride, CCR1 antagonist (ab120811)
Key features and details
- Potent and selective CCR1 antagonist
- CAS Number: 1216540-18-9
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BX 513 hydrochloride, CCR1 antagonist -
Description
Potent and selective CCR1 antagonist -
Alternative names
- VUF 2274
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Biological description
Potent and selective CCR1 antagonist (IC50 = 8.4 μM). Ki values are 0.04 nM (CCR1) and >10 nM (CCR5, CXCR2 and CXCR4). Displays inverse agonist activity for US28, a HCMV-encoded receptor. Able to produce concentration-dependent inhibition of MIP-1α and Ca2+ mobilization.
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Purity
> 99% -
CAS Number
1216540-18-9 -
Chemical structure
Properties
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Chemical name
4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrile hydrochloride -
Molecular weight
481.46 -
Molecular formula
C28H29ClN2O.HCl -
PubChem identifier
9889700 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Clc1ccc(cc1)C4(O)CCN(CCCC(C#N)(c2ccccc2)c3ccccc3)CC4 -
Source
Synthetic
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Research areas
