BQ 788 sodium salt, ETB receptor antagonist (ab144504)
Key features and details
- Highly potent, selective ETB receptor antagonist
- CAS Number: 156161-89-6
- Purity: > 98%
- Soluble in ethanol to 5 mM and in DMSO to 5 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BQ 788 sodium salt, ETB receptor antagonist -
Description
Highly potent, selective ETB receptor antagonist -
Biological description
Highly potent, selective ETB receptor antagonist (IC50 values are 1.2 and 1300 nM for ET-1 binding to ETB and ETA, respectively). Inhibits ET-1 induced vasoconstriction, bronchoconstriction and cell proliferation. Shows antitumor effects.
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Purity
> 98% -
CAS Number
156161-89-6 -
Chemical structure
Properties
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Chemical name
N-[[(2R,6S)-2,6-Dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine sodium salt -
Molecular weight
663.79 -
Molecular formula
C34H50N5NaO7 -
PubChem identifier
23693553 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 5 mM and in DMSO to 5 mM -
Handling
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Solvents listed may be unsuitable for use in biological experiments. These solvents are intended to enable solubilisation and mixing of components. We recommend that biologically unsuitable solvents are removed prior to solubilisation in experimental media.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H]3CCC[C@@H](C)N3C(=O)N[C@@H](CC(C)(C)C)C(=O)N[C@H](Cc2cn(C(C)=O)c1ccccc12)C(=O)N[C@H](CCCC)C(=O)O[Na] -
Source
Synthetic
