BMS202 (PD-1/PD-L1 inhibitor 2), small-molecule inhibitor (ab231311)
Key features and details
- A small-molecule PD-1/PD-L1 interaction inhibitor
- CAS Number: 1675203-84-5
- Purity: > 98%
83 mg/mL (197.84 mM) in DMSO.
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BMS202 (PD-1/PD-L1 inhibitor 2), small-molecule inhibitor -
Description
A small-molecule PD-1/PD-L1 interaction inhibitor -
Alternative names
- BMS202
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Biological description
PD-1/PD-L1 inhibitor 2 is a small-molecule PD-1/PD-L1 interaction inhibitor with an IC50 of 18 nM. Biophysical studies demonstrate that BMS202 binds directly to PD-L1. Binding of BMS202 promotes PD-L1 dimerisation and blocks the PD-L1/ PD1 interaction.
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Purity
> 98% -
CAS Number
1675203-84-5 -
Chemical structure
Properties
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Chemical name
N-[2-[[2-Methoxy-6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl]methylamino]ethyl]acetamide
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Molecular weight
419.53 -
Molecular formula
C25H29N3O3 -
PubChem identifier
117951478 -
Storage instructions
Shipped at 4°C. Store at -20°C. -
Solubility overview
83 mg/mL (197.84 mM) in DMSO.
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SMILES
CC1=C(C=CC=C1COC2=NC(=C(C=C2)CNCCNC(=O)C)OC)C3=CC=CC=C3 -
Source
Synthetic
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Research areas
