BMS-599626 (AC480), HER1 and HER2 inhibitor (ab142063)
Key features and details
- Selective HER1 and HER2 inhibitor
- CAS Number: 8173837-23-1
- Purity: > 99%
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BMS-599626 (AC480), HER1 and HER2 inhibitor -
Description
Selective HER1 and HER2 inhibitor -
Biological description
Selective HER1 and HER2 inhibitor (IC50 values are 20 and 30 nM respectively). Anticancer activity in vitro and in vivo. Orally active. -
Purity
> 99% -
CAS Number
8173837-23-1 -
Chemical structure
Properties
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Chemical name
[(3S)-Morpholin-3-yl]methyl-N-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate hydrochloride -
Molecular weight
567.01 -
Molecular formula
C27H27FN8O3.HCl -
PubChem identifier
46930994 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C2C(=NC=NN2C=C1NC(=O)OCC3COCCN3)NC4=CC5=C(C=C4)N(N=C5)CC6=CC(=CC=C6)F.Cl -
Source
Synthetic
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Research areas