Bisindolylmaleimide III, PKC inhibitor (ab144207)
Key features and details
- Potent PKC inhibitor. Inhibits S6K1, MAPKAP-K1, RSK2 and MSK1 with similar potency.
- CAS Number:
- Purity: > 98%
- Soluble in ethanol and in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Bisindolylmaleimide III, PKC inhibitor -
Description
Potent PKC inhibitor. Inhibits S6K1, MAPKAP-K1, RSK2 and MSK1 with similar potency. -
Biological description
Potent PKC inhibitor (IC50 = 26 nM, PKCα). Inhibits S6K1, MAPKAP-K1, RSK2 and MSK1 with similar potency. Inhibits GSK3β. Inhibits PDK1. Does not show TNFα-dependent apoptotic effects like Bisindolylmaleimide X (ab144211). -
Purity
> 98% -
Chemical structure
Properties
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Chemical name
3-[1-(3-Aminopropyl)indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione -
Molecular weight
384.43 -
Molecular formula
C23H20N4O2 -
PubChem identifier
2398 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol and in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C2C(=C1)C(=CN2)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCN -
Source
Synthetic
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Research areas