Biotin-DEVD-FMK, caspase-3 inhibitor (ab142033)
Key features and details
- Biotin-conjugated, potent, irreversible caspase-3 inhibitor. Cell-permeable.
- CAS Number:
- Purity: > 95%
- Supplied in DMSO (10 mM)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
Biotin-DEVD-FMK, caspase-3 inhibitor -
Description
Biotin-conjugated, potent, irreversible caspase-3 inhibitor. Cell-permeable. -
Biological description
Biotin-conjugated, potent, irreversible caspase-3 inhibitor (IC50 = 35.8 nM). Inhibits apoptosis in multiple biological systems. Neuroprotective and active in vivo. Biotin-conjugation allows detection of activated caspases in conjunction with avidin-tags. Cell-permeable. -
Purity
> 95% -
Chemical structure
Properties
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Molecular weight
873.99 -
Molecular formula
C38H60FN7O13S -
Sequence
DEVD (Modifications: N-terminal biotinyl; C-terminal FMK; Asp-1 = Asp(OMe); Glu-2 = Glu(OMe); Asp-4 = Asp(OMe)) -
PubChem identifier
44135216 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Supplied in DMSO (10 mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(CC(=O)OC)NC(=O)CCCCCNC(=O)CCCCC1C2C(CS1)NC(=O)N2 -
Source
Synthetic
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Research areas