BAY 41-2272, Soluble guanylyl cyclase (sGC) activator (ab144521)
Key features and details
- Soluble guanylyl cyclase (sGC) activator. Potent platelet aggregation inhibitor.
- CAS Number: 256376-24-6
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BAY 41-2272, Soluble guanylyl cyclase (sGC) activator -
Description
Soluble guanylyl cyclase (sGC) activator. Potent platelet aggregation inhibitor. -
Biological description
Soluble guanylyl cyclase (sGC) activator. Induces cGMP synthesis independent of NO. Potent platelet aggregation inhibitor (IC50 = 36 nM). Shows antivasoconstrictive effects (IC50 = 0.30 μM). Induces phagocytosis. Shows vasodilatory effects in vivo. -
Purity
> 98% -
CAS Number
256376-24-6 -
Chemical structure
Properties
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Chemical name
5-Cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine -
Molecular weight
360.39 -
Molecular formula
C20H17FN6 -
PubChem identifier
9798973 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CC1C2=CN=C(N=C2N)C3=NN(C4=C3C=CC=N4)CC5=CC=CC=C5F -
Source
Synthetic
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Research areas
