Banoxantrone dihydrochloride (AQ4N), Topoisomerase II inhibitor (ab144573)
Key features and details
- Bioreductive AQ4 precursor. Topoisomerase II inhibitor.
- CAS Number: 252979-56-9
- Purity: > 97%
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Banoxantrone dihydrochloride (AQ4N), Topoisomerase II inhibitor -
Description
Bioreductive AQ4 precursor. Topoisomerase II inhibitor. -
Biological description
Bioreductive AQ4 precursor. Topoisomerase II inhibitor. Converts under hypoxia to DNA-affinic mitoxantrone (ab141041) structural analog. Induces DNA intercalation. Shows antitumor effects in vivo.
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Purity
> 97% -
CAS Number
252979-56-9 -
Chemical structure
Properties
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Chemical name
1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride -
Molecular weight
517.41 -
Molecular formula
C22H28N4O6.2HCl -
PubChem identifier
72941779 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in water to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[N+](C)(CCNC1=C2C(=C(C=C1)NCC[N+](C)(C)[O-])C(=O)C3=C(C=CC(=C3C2=O)O)O)[O-].Cl.Cl -
Source
Synthetic
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Research areas
