Antibodies, Proteins, Kits and Reagents for Life Science

Key features and details

Product name

Anti-Tomosyn antibody
See all Tomosyn primary antibodies
Description

Rabbit polyclonal to Tomosyn
Host species

Rabbit
Tested Applications & Species

Application Species
WB
Rat

See all applications and species data
Immunogen

Synthetic peptide corresponding to Human Tomosyn aa 850-950 conjugated to keyhole limpet haemocyanin.
(Peptide available as ab45227)
Positive control
- This antibody gave a positive signal in the following tissues lysates: Rat Brain, Mouse Brain and Human Brain

Form

Liquid
Storage instructions

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage buffer

pH: 7.40
Preservative: 0.02% Sodium azide
Constituent: PBS

Batches of this product that have a concentration
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Purity

Immunogen affinity purified
Clonality

Polyclonal
Isotype

IgG
Research areas

Our Abpromise guarantee covers the use of ab45228 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application	Species
WB	Rat

Application	Abreviews	Notes
WB		Use a concentration of 1 µg/ml. Detects a band of approximately 128 kDa (predicted molecular weight: 128 kDa).

Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 128 kDa (predicted molecular weight: 128 kDa).

Relevance

Tomosyn plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release by inhibiting the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane, via the displacement of munc18 from syntaxin-1. There are three splice variants of tomosyn designated m-tomosyn, b-tomosyn and s-tomosyn. Although b-tomosyn is ubiquitously expressed, s-tomosyn and m-tomosyn are expressed primarily in brain.
Cellular localization

Cell Membrane and Cytoplasmic. Note: Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles
Database links
- Entrez Gene: 134957 Human
- Entrez Gene: 78808 Mouse
- Entrez Gene: 81022 Rat
- Omim: 604586 Human
- SwissProt: Q5T5C0 Human
- SwissProt: Q8K400 Mouse
- SwissProt: Q9WU70 Rat
- Unigene: 93534 Human
- Unigene: 331751 Mouse
- Unigene: 96029 Rat
see all
Alternative names
- FLJ30922 antibody
- Lethal(2) giant larvae protein homolog 3 antibody
- LGL3 antibody
- LLGL3 antibody
- MGC141942 antibody
- MGC141968 antibody
- Nbla04300 antibody
- STXBP5 antibody
- Syntaxin binding protein 5 antibody
- Tomosyn 1 antibody
see all

Publishing research using ab45228? Please let us know so that we can cite the reference in this datasheet.

ab45228 has not yet been referenced specifically in any publications.