Anti-PHAP1 antibody
See all PHAP1 primary antibodies

Rabbit polyclonal to PHAP1

Rabbit

This antibody does not cross react with PHAP12a or PHAPIII isoforms.

Suitable for: WB, ICC/IF, IHC-Pmore details

Reacts with: Mouse, Rat, Human

Synthetic peptide within Human PHAP1 aa 199-249 (C terminal). The exact sequence is proprietary. A peptide corresponding to 14 amino acids near the carboxy terminus of human PHAP1.
(Peptide available as ab6240)

Liquid

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Stable for 12 months at -20°C.

pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS

Immunogen affinity purified

Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and –7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-mediated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-mediated cell transformation.

Polyclonal

IgG

• Cell Biology
• Apoptosis
• Intracellular
• Caspases etc
• Caspases

• Cell Biology
• Apoptosis
• Mitochondrial

• Cancer
• Oncoproteins/suppressors
• Tumor suppressors
• Other

• Metabolism
• Pathways and Processes
• Mitochondrial Metabolism
• Mitochondrial markers

• Metabolism
• Pathways and Processes
• Metabolism processes
• Apoptosis

• Cancer
• Cell Death
• Apoptosis
• Mitochondrial

• Cancer
• Cell Death
• Apoptosis
• Metabolism